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Identify regulatory T cells and cytotoxic T cells withing the tumor context. This T-reg 4-plex/5-color kit enables the characterization of different T cells and how they regulate immune response. This kit contains all reagents needed to stain and image CD4, CD8, FoxP3, panCK / SOX10 along with a nuclear counterstain.
Marker |
Main Cell |
Function |
CD4 |
Helper T cell |
T-helper cells play an important role in the adaptive immune system by helping regulate the immune response. The main cellular phenotype that expresses CD4 is mature helper T cells. |
CD8 |
Cytotoxic T cells |
Cytotoxic T cells are responsible for mediating apoptosis of cancer cells through the release of perforin and granzyme B from the T cells. |
FoxP3 |
Regulatory T cell |
FoxP3 is a transcription factor and often regarded as a master regulator of regulatory T cells. Regulatory T cells expressing FoxP3 generally decrease the immune response and can prevent tumor cell infiltration. Recent evidence suggests that FoxP3 is transiently expressed by activated T cells. |
CK/Sox10 |
Tumor cell |
The kit may be used to interrogate many tumor sample types for Research. A cocktail of optimized reagents for the detection of pan-Cytokeratin and Sox10 protein markers is provided. Cytokeratins are expressed in cells of an epithelial origin including most carcinomas. Sox10 is expressed in cells derived from the neural crest including melanocytes that give rise to melanomas. |
품번 | 품명 |
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UltiMapper I/O T-reg |