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Identify Myeloid-Derived Suppressor Cells within the tumor microenvironment. This MDSC 4-plex/5-color kit enables the characterization of myeloid-derived suppressor cell populations into M-MDSCs and PMN-MDSCs. This kit contains all reagents needed to stain and image CD11b, CD14, CD15, HLA-DR, along with a nuclear counterstain.
Marker |
Main Cell |
Function |
CD 11b |
Myeloid Cell |
CD 11b is primarily expressed on cells of a myeloid lineage. Myeloid cells differentiate into specific cell types such as neutrophils, monocytes, macrophages, and dendritic cells. |
CD 14 |
Monocyte |
Monocytes are large myeloid cells that can often differentiate into macrophages and dendritic cells These cells coexpress CD14 and HLA-DR. In the context of MDSCs, M-MDSCs are in a paused status on their path from myeloid to monocyte differentiation and express CD14, but lack HLA-DR expression. |
CD 15 |
Granulocyte |
Granulocytes are a type of myeloid cell that are characterized by the presence of granules in the cytoplasm, and have a varying nuclear shape; often termed as polymorphonuclear(PMN) leukocytes. Granulocytes can differentiate into neutrophils (prominent cell type), eosinophils, basophils, and mast cells. In the context of MDSCs, PMN-MDSCs are in a paused state on their development path from myeloid to neutrophil differentiation and express CD15, but lack of weekly express HLA-DR. |
HLA-DR |
Antigen-presenting cell |
Human leukocyte antigen (HLA) complex encodes the major histocompatibility complex(MHC). HLA-DR is the main isotype of 3 isotype(-DR.-DP, DQ) responsible for presentation of antigens to T cells and B cells. Often, HLA-DR is sued as a marker indicating the presence of antigen-presenting cells(APC). |
품번 | 품명 |
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UltiMapper I/O MDSC |