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UltiMapper I/O MDSC

UltiMapper I/O MDSC


Identify Myeloid-Derived Suppressor Cells within the tumor microenvironment. This MDSC 4-plex/5-color kit enables the characterization of myeloid-derived suppressor cell populations into M-MDSCs and PMN-MDSCs. This kit contains all reagents needed to stain and image CD11b, CD14, CD15, HLA-DR, along with a nuclear counterstain.


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 Main Cell


 CD 11b

 Myeloid Cell

CD 11b is primarily expressed on cells of a myeloid lineage. Myeloid cells differentiate into specific cell types such as neutrophils, monocytes, macrophages, and dendritic cells. 

 CD 14


Monocytes are large myeloid cells that can often differentiate into macrophages and dendritic cells These cells coexpress CD14 and HLA-DR. 

In the context of MDSCs, M-MDSCs are in a paused status on their path from myeloid to monocyte differentiation and express CD14, but lack HLA-DR expression. 

 CD 15


Granulocytes are a type of myeloid cell that are characterized by the presence of granules in the cytoplasm, and have a varying nuclear shape; often termed as polymorphonuclear(PMN) leukocytes. Granulocytes can differentiate into neutrophils (prominent cell type), eosinophils, basophils, and mast cells. In the context of MDSCs, PMN-MDSCs are in a paused state on their development path from myeloid to neutrophil differentiation and express CD15, but lack of weekly express HLA-DR.


 Antigen-presenting cell

Human leukocyte antigen (HLA) complex encodes the major histocompatibility complex(MHC). HLA-DR is the main isotype of 3 isotype(-DR.-DP, DQ) responsible for presentation of antigens to T cells and B cells. Often, HLA-DR is sued as a marker indicating the presence of antigen-presenting cells(APC).



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UltiMapper I/O MDSC