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UltiMapper I/O T-act

UltiMapper I/O T-act

Ulitvue

Determine whether T cells have the potential to mediate cell death. This T cell activation 4-plex/5-color kit enables co-expression of proliferating cells, cytotoxic cells, tumor cells, and the underlying proliferative index and potential for T cell mediated death.

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Marker Main Cell Function
CD3 T cell

   

    Identifies all T cells and is the most specific marker for T cells, including lineage based markers such as CD4 and CD8.  


Granzyme B Cytotoxic T cells & NK cells

    Granzyme B is produced, stored, and released by cytotoxic cells to mediate cellular death in combination with Perforin.

Ki67Proliferation

    Ki67 is expressed within the nucleus during the phases of mitosis and is strongly associated with cell proliferation.

PanCK/Sox10 Tumor Cell

   

   The kit may be used to interrogate many tumor sample types for Research.

   A cocktail of optimized reagents for the detection of pan-Cytokeratin and Sox10 protein markers is provided. 

   Cytokeratins are expressed in cells of an epithelial origin including most carcinomas.

   Sox10 is expressed in cells derived from the neural crest including melanocytes that give rise to melanomas.

 

 

  

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UltiMapper I/O T-act